Exercise Beats Drugs to Prevent Cancer Recurrence: Trial

A global trial has found that exercise can lower the risk of cancer returning and reduce death rates by up to a third after treatment. This groundbreaking study included patients from countries such as the US, UK, Australia, France, Canada, and Israel. It showed that a structured exercise program following cancer treatment is more effective at stopping the disease from coming back than many current drug treatments.

The research was presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago and published in the New England Journal of Medicine. It may lead to major changes in health guidelines worldwide, encouraging doctors to recommend exercise as part of post-treatment care.

The trial enrolled 889 colon cancer patients between 2009 and 2023, most with stage three disease. Participants were divided into two groups. One group followed a supervised exercise program with personal trainers or health coaches, while the other received only a healthy lifestyle booklet.

Those in the exercise group met trainers twice a month initially and later once a month for three years. They aimed to complete the equivalent of three to four walks lasting 45 to 60 minutes each week, choosing activities they enjoyed such as walking, kayaking, or skiing.

After five years, the group that exercised had a 28 percent lower risk of cancer returning or developing new tumors compared to the non-exercise group. After eight years, the same group showed a 37 percent lower risk of death.

Experts agree this is the highest quality evidence to date showing that exercise can significantly improve survival chances for cancer patients. The benefits of exercise were found to be as large or even greater than many approved cancer drugs, which often come with side effects and high costs.

Exercise helps by strengthening the immune system, reducing inflammation, and maintaining a healthy weight. It also improves patients’ mood and energy levels. Unlike drug treatments, exercise is low-cost and has minimal risks.

Although the study focused on colon cancer, early data suggests that similar benefits might apply to other common cancers such as breast and prostate. This means exercise could soon become a standard recommendation for many cancer survivors.

The findings highlight the need for healthcare providers to offer tailored exercise programs for cancer patients after treatment. Personal trainers or health coaches can support patients in meeting their activity goals safely and effectively.

Global cancer care guidelines are expected to change as a result of this trial. Patients who complete treatment are encouraged to discuss exercise plans with their doctors to improve their long-term health and survival.